Ontology highlight
ABSTRACT:
SUBMITTER: Kamenova I
PROVIDER: S-EPMC6465333 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190415 1
Cells dedicate significant energy to build proteins often organized in multiprotein assemblies with tightly regulated stoichiometries. As genes encoding subunits assembling in a multisubunit complex are dispersed in the genome of eukaryotes, it is unclear how these protein complexes assemble. Here, we show that mammalian nuclear transcription complexes (TFIID, TREX-2 and SAGA) composed of a large number of subunits, but lacking precise architectural details are built co-translationally. We demon ...[more]