Heritability and genome-wide association study of benign prostatic hyperplasia (BPH) in the eMERGE network.

ABSTRACT: Benign prostatic hyperplasia (BPH) results in a significant public health burden due to the morbidity caused by the disease and many of the available remedies. As much as 70% of men over 70 will develop BPH. Few studies have been conducted to discover the genetic determinants of BPH risk. Understanding the biological basis for this condition may provide necessary insight for development of novel pharmaceutical therapies or risk prediction. We have evaluated SNP-based heritability of BPH in two cohorts and conducted a genome-wide association study (GWAS) of BPH risk using 2,656 cases and 7,763 controls identified from the Electronic Medical Records and Genomics (eMERGE) network. SNP-based heritability estimates suggest that roughly 60% of the phenotypic variation in BPH is accounted for by

SUBMITTER: Hellwege JN 

PROVIDER: S-EPMC6465359 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature