Changes in urinary metabolome related to body fat involve intermediates of choline processing by gut microbiota.

ABSTRACT: Countering the obesity pandemic will require better understanding of disease mechanisms and development of new diagnostic methods. Small molecule metabolites excreted in urine can be important biomarkers of disease progression and treatment. However, with multiple pathways involved, it has been challenging to identify key pathway(s) that closely follow disease features such as body fat. We employed a high-fat diet (HFD) mouse model of obesity with the goal of determining changes in urinary metabolite profile related to body fat using proton nuclear magnetic resonance (¹H NMR). Several urinary metabolites with significantly lower levels in HFD compared to control mice have been identified. Specifically, major changes were found in metabolites from tricarboxylic acid (TCA) cycle,

SUBMITTER: Stec DF 

PROVIDER: S-EPMC6465582 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature