Correlation between PLCE1 rs2274223 variant and digestive tract cancer: A meta-analysis.

ABSTRACT:

Background

The relationship between phospholipase C ε-1 (PLCE1) rs2274223 variant and digestive tract cancer remains inconclusive despite extensive investigations. Therefore, we performed this meta-analysis to obtain a more credible conclusion.

Methods

PubMed, Medline, and Embase were systematic searched. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.

Results

A total of 27 studies were finally included. Pooled analyses suggested that PLCE1 rs2274223 variant was significantly correlated with the likelihood of esophageal cancer (dominant model: p < 0.001, OR = 0.77, 95% CI 0.72-0.83; recessive model: p < 0.001, OR = 1.28, 95% CI 1.12-1.45; additive model: p < 0.001, OR = 1.20, 95% CI 1.11-1.29; allele model: p < 0.001, OR = 0.80, 95% CI 0.74-0.88)

SUBMITTER: Chen Q 

PROVIDER: S-EPMC6465661 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature