Association between polymorphisms in CXCR2 gene and preeclampsia.

ABSTRACT:

Background

Preeclampsia is a serious pregnancy-specific syndrome with incompletely understood pathogenesis. Previous study has demonstrated that the decreased CXCR2 in preeclamptic placentas may contribute to the development of preeclampsia. The role of single nucleotide polymorphisms (SNPs) of CXCR2 gene in the pathogenesis of preeclampsia remains largely unexplored. Thus, we aimed to investigate the association between polymorphisms of CXCR2 gene and preeclampsia in Han Chinese women.

Methods

Totally 481 pregnant women, including 243 controls and 238 patients with preeclampsia were recruited. The rs1126579 and rs2230054 polymorphisms in CXCR2 gene were tested using polymerase chain reaction-restriction fragment length polymorphism method.

Results

Significantly incre

SUBMITTER: Chen H 

PROVIDER: S-EPMC6465673 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature