Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma.

ABSTRACT:

Background

Cellular senescence is a recognized barrier for progression of chronic liver diseases to hepatocellular carcinoma (HCC). The expression of a cluster of genes is altered in response to environmental factors during senescence. However, it is questionable whether these genes could serve as biomarkers for HCC patients.

Aim

To develop a signature of senescence-associated genes (SAGs) that predicts patients' overall survival (OS) to improve prognosis prediction of HCC.

Methods

SAGs were identified using two senescent cell models. Univariate COX regression analysis was performed to screen the candidate genes significantly associated with OS of HCC in a discovery cohort (GSE14520) for the least absolute shrinkage and selection operator modelling. Prognostic value o

SUBMITTER: Xiang XH 

PROVIDER: S-EPMC6465944 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature