Enhanced Autophagy Contributes to Reduced Viral Infection in Black Flying Fox Cells.

ABSTRACT: Bats are increasingly implicated as hosts of highly pathogenic viruses. The underlying virus⁻host interactions and cellular mechanisms that promote co-existence remain ill-defined, but physiological traits such as flight and longevity are proposed to drive these adaptations. Autophagy is a cellular homeostatic process that regulates ageing, metabolism, and intrinsic immune defense. We quantified basal and stimulated autophagic responses in black flying fox cells, and demonstrated that although black flying fox cells are susceptible to Australian bat lyssavirus (ABLV) infection, viral replication is dampened in these bat cells. Black flying fox cells tolerated prolonged ABLV infection with less cell death relative to comparable human cells, suggesting post-entry mechanisms interference with

SUBMITTER: Laing ED 

PROVIDER: S-EPMC6466025 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature