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A Novel Hepacivirus in Wild Rodents from South America.

ABSTRACT: The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.

SUBMITTER: de Souza WM

PROVIDER: S-EPMC6466192 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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A Novel Hepacivirus in Wild Rodents from South America.

de Souza William Marciel WM Fumagalli Marcílio Jorge MJ Sabino-Santos Gilberto G Motta Maia Felipe Gonçalves FG Modha Sejal S Teixeira Nunes Márcio Roberto MR Murcia Pablo Ramiro PR Moraes Figueiredo Luiz Tadeu LT

Viruses 20190324 3

The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigrip ...[more]

PMID: 30909631

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