Histone 4 Lysine 20 Methylation: A Case for Neurodevelopmental Disease.

ABSTRACT: Neurogenesis is an elegantly coordinated developmental process that must maintain a careful balance of proliferation and differentiation programs to be compatible with life. Due to the fine-tuning required for these processes, epigenetic mechanisms (e.g., DNA methylation and histone modifications) are employed, in addition to changes in mRNA transcription, to regulate gene expression. The purpose of this review is to highlight what we currently know about histone 4 lysine 20 (H4K20) methylation and its role in the developing brain. Utilizing publicly-available RNA-Sequencing data and published literature, we highlight the versatility of H4K20 methyl modifications in mediating diverse cellular events from gene silencing/chromatin compaction to DNA double-stranded break repair. From large-sc

SUBMITTER: Wickramasekara RN 

PROVIDER: S-EPMC6466304 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature