Cat and Mouse: HIV Transcription in Latency, Immune Evasion and Cure/Remission Strategies.

ABSTRACT: There is broad scientific and societal consensus that finding a cure for HIV infection must be pursued. The major barrier to achieving a cure for HIV/AIDS is the capacity of the HIV virus to avoid both immune surveillance and current antiretroviral therapy (ART) by rapidly establishing latently infected cell populations, termed latent reservoirs. Here, we provide an overview of the rapidly evolving field of HIV cure/remission research, highlighting recent progress and ongoing challenges in the understanding of HIV reservoirs, the role of HIV transcription in latency and immune evasion. We review the major approaches towards a cure that are currently being explored and further argue that small molecules that inhibit HIV transcription, and therefore uncouple HIV gene expression from signals

SUBMITTER: Delannoy A 

PROVIDER: S-EPMC6466452 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature