Overlap between eQTL and QTL associated with production traits and fertility in dairy cattle.

ABSTRACT:

Background

Identifying causative mutations or genes through which quantitative trait loci (QTL) act has proven very difficult. Using information such as gene expression may help to identify genes and mutations underlying QTL. Our objective was to identify regions associated both with production traits or fertility and with gene expression, in dairy cattle. We used three different approaches to discover QTL that are also expression QTL (eQTL): 1) estimate the correlation between local genomic estimated breeding values (GEBV) and gene expression, 2) investigate whether the 300 intervals explaining most genetic variance for a trait contain more eQTL than 300 randomly selected intervals, and 3) a colocalisation analysis. Phenotypes and genotypes up to sequence level of 35,775 dairy bul

SUBMITTER: van den Berg I 

PROVIDER: S-EPMC6466667 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature