Dataset Information

Optimal management after paediatric lumbar puncture: a randomized controlled trial.

ABSTRACT:

Background

To evaluate whether a shorter time of lying supine without a pillow and fasting for solids and liquids (LSFSL) after a lumbar puncture (LP) is associated with a higher risk of post-lumbar puncture headache (PLPH) and post-lumbar puncture lower back pain (PLPBP) in a randomized, assessor-blinded, controlled trial.

Methods

Paediatric patients who underwent their first LP after hospital admission were randomly allocated to either the group with half an hour of LSFSL (0.5 h LSFSL) or 4 h of LSFSL (4 h LSFSL) immediately after LP. The primary outcome is PLPH after LP. The incidence of PLPH, PLPBP, and vomiting; vital signs (respiratory rate, heart rate, blood pressure); and other post-procedure conditions after LP were measured as the outcomes. The Non-inferiority test and Wilcoxon rank-sum test were used to analyse the outcome data.

Results

In total, 400 patients (201 in the 0.5-h LSFSL group and 199 in the 4-h LSFSL group) were included in this trial. Twelve (5.97%) of 201 patients experienced PLPH in the 0.5 h LSFSL group versus 13 (6.53%) of 199 patients in the 4 h LSFSL group (difference 0.56, 95% CI -4.18 to 5.31; p = 0·0108 for the non-inferiority test). Fourteen (6.97%) of 201 patients experienced PLPBP in the 0.5 h LSFSL group versus 17 (8.54%) of 199 patients in the 4 h LSFSL group (difference 1.57, 95% CI -3.66 to 6.82; p = 0.007 for the non-inferiority test). The changes in heart rate (HR), respiratory rate (RP) and systolic blood pressure (SBP) before and after the LP were not different between the 0.5-h LSFSL group and the 4-h LSFSL group. No other adverse events were reported.

Conclusions

Compared with 4 h of LSFSL after LP, 0.5 h of LSFSL was not associated with a higher risk of PLPH, PLPBP or other adverse events. In conclusion, 0.5 h of LSFSL is sufficient for children undergoing LP.

Trial registration

Clinical trial NCT02590718 . The date of registration was 08/25/2015.

SUBMITTER: Hu B

PROVIDER: S-EPMC6466704 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Optimal management after paediatric lumbar puncture: a randomized controlled trial.

Hu Bing B Chen Tian-Ming TM Liu Bing B Chi Wei W Miao Yi-Qing YQ Nie Xiao-Lu XL Peng Xiao-Xia XX Liu Gang G

BMC neurology 20190413 1

<h4>Background</h4>To evaluate whether a shorter time of lying supine without a pillow and fasting for solids and liquids (LSFSL) after a lumbar puncture (LP) is associated with a higher risk of post-lumbar puncture headache (PLPH) and post-lumbar puncture lower back pain (PLPBP) in a randomized, assessor-blinded, controlled trial.<h4>Methods</h4>Paediatric patients who underwent their first LP after hospital admission were randomly allocated to either the group with half an hour of LSFSL (0.5 h ...[more]

PMID: 30987603

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Dataset Information

Optimal management after paediatric lumbar puncture: a randomized controlled trial.

Background

Methods

Results

Conclusions

Trial registration

Publications

Optimal management after paediatric lumbar puncture: a randomized controlled trial.

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