Altered expression of the CSMD1 gene in the peripheral blood of schizophrenia patients.

ABSTRACT:

Background

Schizophrenia (SCZ) is a heritable, refractory, and devastating psychiatric disorder. Previous studies have shown that the variants of CUB and sushi multiple domains 1 (CSMD1) demonstrate significant genome-wide association with SCZ. However, few studies have been conducted on the effect of antipsychotics on the expression levels of CSMD1. This study explored whether a change occurs in the expression of the CSMD1 gene before and after antipsychotic treatment in SCZ patients.

Methods

The study population comprised Han Chinese patients from eastern China, including 32 SCZ patients and 48 healthy controls. The expression of CSMD1 before and after treatment in the SCZ group and between the two groups was analyzed using real-time quantitative polymerase chain reaction

SUBMITTER: Liu Y 

PROVIDER: S-EPMC6466712 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature