Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies.

ABSTRACT:

Background

Malaria is a major global health problem, with the Plasmodium falciparum protozoan parasite causing the most severe form of the disease. Prevalence of drug-resistant P. falciparum highlights the need to understand the biology of resistance and to identify novel combination therapies that are effective against resistant parasites. Resistance has compromised the therapeutic use of many antimalarial drugs, including chloroquine, and limited our ability to treat malaria across the world. Fortunately, chloroquine resistance comes at a fitness cost to the parasite; this can be leveraged in developing combination therapies or to reinstate use of chloroquine.

Results

To understand biological changes induced by chloroquine treatment, we compared transcriptomics data from c

SUBMITTER: Untaroiu AM 

PROVIDER: S-EPMC6466727 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature