Retinal alterations in a pre-clinical model of an autism spectrum disorder.

ABSTRACT:

Background

Autism spectrum disorders (ASD) affect around 1.5% of people worldwide. Symptoms start around age 2, when children fail to maintain eye contact and to develop speech and other forms of communication. Disturbances in glutamatergic and GABAergic signaling that lead to synaptic changes and alter the balance between excitation and inhibition in the developing brain are consistently found in ASD. One of the hallmarks of these disorders is hypersensitivity to sensory stimuli; however, little is known about its underlying causes. Since the retina is the part of the CNS that converts light into a neuronal signal, we set out to study how it is affected in adolescent mice prenatally exposed to valproic acid (VPA), a useful tool to study ASD endophenotypes.

Methods

Pregnant

SUBMITTER: Guimaraes-Souza EM 

PROVIDER: S-EPMC6466731 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature