Manganese-Catalyzed α-Alkylation of Ketones, Esters, and Amides Using Alcohols.

ABSTRACT: Herein we report the manganese-catalyzed C-C bond-forming reactions via α-alkylation of ketones, amides, and esters, using primary alcohols. β-Alkylation of secondary alcohols by primary alcohols to obtain α-alkylated ketones is also reported. The reactions are catalyzed by a ( ⁱ Pr-PNP)Mn(H)(CO)₂ pincer complex under mild conditions in the presence of (catalytic) base liberating water (and H₂ in the case of secondary alcohol alkylation) as the sole byproduct.

SUBMITTER: Chakraborty S 

PROVIDER: S-EPMC6466737 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature