RSPO3 is a prognostic biomarker and mediator of invasiveness in prostate cancer.

ABSTRACT:

Background

While prostate cancer can often manifest as an indolent disease, the development of locally-advanced or metastatic disease can cause significant morbidity or mortality. Elucidation of molecular mechanisms contributing to disease progression is crucial for more accurate prognostication and effective treatments. R-Spondin 3 (RSPO3) is a protein previously implicated in the progression of colorectal and lung cancers. However, a role for RSPO3 in prostate cancer prognosis and behaviour has not been explored.

Methods

We compare the relative levels of RSPO3 expression between normal prostate tissue and prostate cancer in two independent patient cohorts (Taylor and GSE70768-Cambridge). We also examine the association of biochemical relapse with RSPO3 levels in these coho

SUBMITTER: Mesci A 

PROVIDER: S-EPMC6466739 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature