Evaluation of intravenous lidocaine in head and neck cancer surgery: study protocol for a randomized controlled trial.

ABSTRACT:

Background

Pain after major head and neck cancer surgery is underestimated and has both nociceptive and neuropathic characteristics. Extended resection, flap coverage, nerve lesions, inflammation, and high-dose opioid administration can also lead to hyperalgesia and chronic postoperative pain. Opioids are frequently associated with adverse events such as dizziness, drowsiness, nausea and vomiting, or constipation disturbing postoperative recovery and extending the length of hospital stay. Patients eligible for major head and neck cancer surgery cannot benefit from full multimodal pain management with locoregional anesthesia. Intravenous lidocaine, investigated in several studies, has been found to decrease acute pain and morphine consumption. Some data suggest also that it can prev

SUBMITTER: Omar E 

PROVIDER: S-EPMC6466788 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature