Going beyond base-pairs: topology-based characterization of base-multiplets in RNA.

ABSTRACT: Identification and characterization of base-multiplets, which are essentially mediated by base-pairing interactions, can provide insights into the diversity in the structure and dynamics of complex functional RNAs, and thus facilitate hypothesis driven biological research. The necessary nomenclature scheme, an extension of the geometric classification scheme for base-pairs by Leontis and Westhof, is however available only for base-triplets. In the absence of information on topology, this scheme is not applicable to quartets and higher order multiplets. Here we propose a topology-based classification scheme which, in conjunction with a graph-based algorithm, can be used for the automated identification and characterization of higher order base-multiplets in RNA structures. Here, the RNA str

SUBMITTER: Bhattacharya S 

PROVIDER: S-EPMC6467009 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature