Neurochemical correlates of functional decline in amyotrophic lateral sclerosis.

ABSTRACT:

Objective

To determine whether proton magnetic resonance spectroscopy (¹H-MRS) can detect neurochemical changes in amyotrophic lateral sclerosis (ALS) associated with heterogeneous functional decline.

Methods

Nineteen participants with early-stage ALS and 18 age-matched and sex ratio-matched controls underwent ultra-high field ¹H-MRS scans of the upper limb motor cortex and pons, ALS Functional Rating Scale-Revised (ALSFRS-R total, upper limb and bulbar) and upper motor neuron burden assessments in a longitudinal observational study design with follow-up assessments at 6 and 12 months. Slopes of neurochemical levels over time were compared between patient subgroups classified by the rate of upper limb or bulbar functional decline. ¹H-MRS and

SUBMITTER: Cheong I 

PROVIDER: S-EPMC6467050 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature