Age-related alterations in axonal microstructure in the corpus callosum measured by high-gradient diffusion MRI.

ABSTRACT: Cerebral white matter exhibits age-related degenerative changes during the course of normal aging, including decreases in axon density and alterations in axonal structure. Noninvasive approaches to measure these microstructural alterations throughout the lifespan would be invaluable for understanding the substrate and regional variability of age-related white matter degeneration. Recent advances in diffusion magnetic resonance imaging (MRI) have leveraged high gradient strengths to increase sensitivity toward axonal size and density in the living human brain. Here, we examined the relationship between age and indices of axon diameter and packing density using high-gradient strength diffusion MRI in 36 healthy adults (aged 22-72) in well-defined central white matter tracts in the brain. A r

SUBMITTER: Fan Q 

PROVIDER: S-EPMC6467051 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature