Impact of HLA Allele-KIR Pairs on HIV Clinical Outcome in South Africa.

ABSTRACT:

Background

HLA class I contributes to HIV immune control through antigen presentation to cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells. In contrast to investigations of CTL, studies of NK cells in HIV control through HLA-killer immunoglobulin-like receptor (KIR) interactions remain sparse in African cohorts.

Methods

Treatment-naive, chronically HIV-infected adults (N = 312) were recruited from South Africa, and the effects of HLA-KIR pairs on clinical outcome were analyzed.

Results

There was no significant difference in viral load among all subjects with HLA alleles from the HLA-C1 group (P = .1). However, differences in HLA-C type significantly influenced viremia among 247 KIR2DL3 positives (P = .04), suggesting that specific HLA-KIR interactions contr

SUBMITTER: Mori M 

PROVIDER: S-EPMC6467198 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature