Antimicrobial Microwebs of DNA-Histone Inspired from Neutrophil Extracellular Traps.

ABSTRACT: Neutrophil extracellular traps (NETs) are decondensed chromatin networks released by neutrophils that can trap and kill pathogens but can also paradoxically promote biofilms. The mechanism of NET functions remains ambiguous, at least in part, due to their complex and variable compositions. To unravel the antimicrobial performance of NETs, a minimalistic NET-like synthetic structure, termed "microwebs," is produced by the sonochemical complexation of DNA and histone. The prepared microwebs have structural similarity to NETs at the nanometer to micrometer dimensions but with well-defined molecular compositions. Microwebs prepared with different DNA to histone ratios show that microwebs trap pathogenic Escherichia coli in a manner similar to NETs when the zeta potential of the microwebs is po

SUBMITTER: Song Y 

PROVIDER: S-EPMC6467213 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature