Examining the neurochemical underpinnings of animal models of risky choice: Methodological and analytic considerations.

ABSTRACT: Because risky choice is associated with several psychiatric conditions, recent research has focused on examining the underlying neurochemical processes that control risk-based decision-making. Not surprisingly, several tasks have been developed to study the neural mechanisms involved in risky choice. The current review will briefly discuss the major tasks used to measure risky choice and will summarize the contribution of several major neurotransmitter systems to this behavior. To date, the most common measures of risky choice are the probability discounting task, the risky decision task, and the rat gambling task. Across these three tasks, the contribution of the dopaminergic system has been most studied, although the effects of serotonergic, adrenergic, cholinergic, and glutamatergic lig

SUBMITTER: Yates JR 

PROVIDER: S-EPMC6467223 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature