Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

ABSTRACT:

Background

A nonsputum blood test capable of predicting progression of healthy individuals to active tuberculosis (TB) before clinical symptoms manifest would allow targeted treatment to curb transmission. We aimed to develop a proteomic biomarker of risk of TB progression for ultimate translation into a point-of-care diagnostic.

Methods and findings

Proteomic TB risk signatures were discovered in a longitudinal cohort of 6,363 Mycobacterium tuberculosis-infected, HIV-negative South African adolescents aged 12-18 years (68% female) who participated in the Adolescent Cohort Study (ACS) between July 6, 2005 and April 23, 2007, through either active (every 6 months) or passive follow-up over 2 years. Forty-six individuals developed microbiologically confirmed TB disease within

SUBMITTER: Penn-Nicholson A 

PROVIDER: S-EPMC6467365 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature