Oxalate deposition in renal allograft biopsies within 3 months after transplantation is associated with allograft dysfunction.

ABSTRACT:

Background

Calcium oxalate (CaOx) deposition in the kidney may lead to loss of native renal function but little is known about the prevalence and role of CaOx deposition in transplanted kidneys.

Methods

In patients transplanted in 2014 and 2015, all for-cause renal allograft biopsies obtained within 3 months post-transplantation were retrospectively investigated for CaOx deposition. Additionally, all preimplantation renal biopsies obtained in 2000 and 2001 were studied.

Results

In 2014 and 2015, 388 patients were transplanted, of whom 149 had at least one for-cause renal biopsy. Twenty-six (17%) patients had CaOx deposition. In the population with CaOx deposition: Patients had significantly more often been treated with dialysis before transplantation (89 vs. 64%; p =

SUBMITTER: Snijders MLH 

PROVIDER: S-EPMC6467373 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature