Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan.

ABSTRACT: A comprehensive description of the phenotypic changes during cellular aging is key towards unraveling its causal forces. Previously, we mapped age-related changes in the proteome and transcriptome (Janssens et al., 2015). Here, employing the same experimental procedure and model-based inference, we generate a comprehensive account of metabolic changes during the replicative life of Saccharomyces cerevisiae. With age, we found decreasing metabolite levels, decreasing growth and substrate uptake rates accompanied by a switch from aerobic fermentation to respiration, with glycerol and acetate production. The identified metabolic fluxes revealed an increase in redox cofactor turnover, likely to combat increased production of reactive oxygen species. The metabolic changes are possibly a

SUBMITTER: Leupold S 

PROVIDER: S-EPMC6467564 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature