MYC Drives Group 3 Medulloblastoma through Transformation of Sox2⁺ Astrocyte Progenitor Cells.

ABSTRACT: A subset of group 3 medulloblastoma frequently harbors amplification or overexpression of MYC lacking additional focal aberrations, yet it remains unclear whether MYC overexpression alone can induce tumorigenesis and which cells give rise to these tumors. Here, we showed that astrocyte progenitors in the early postnatal cerebellum were susceptible to transformation by MYC. The resulting tumors specifically resembled human group 3 medulloblastoma based on histology and gene-expression profiling. Gene-expression analysis of MYC-driven medulloblastoma cells revealed altered glucose metabolic pathways with marked overexpression of lactate dehydrogenase A (LDHA). LDHA abundance correlated positively with MYC expression and was associated with poo

SUBMITTER: Tao R 

PROVIDER: S-EPMC6467710 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature