Ontology highlight
ABSTRACT:
SUBMITTER: Augello MA
PROVIDER: S-EPMC6467783 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Cancer cell 20190328 4
Deletion of the gene encoding the chromatin remodeler CHD1 is among the most common alterations in prostate cancer (PCa); however, the tumor-suppressive functions of CHD1 and reasons for its tissue-specific loss remain undefined. We demonstrated that CHD1 occupied prostate-specific enhancers enriched for the androgen receptor (AR) and lineage-specific cofactors. Upon CHD1 loss, the AR cistrome was redistributed in patterns consistent with the oncogenic AR cistrome in PCa samples and drove tumor ...[more]