The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease.

ABSTRACT:

Background

PD is a complex polygenic disorder. In recent years, several genes from the endocytic membrane-trafficking pathway have been suggested to contribute to disease etiology. However, a systematic analysis of pathway-specific genetic risk factors is yet to be performed.

Objectives

To comprehensively study the role of the endocytic membrane-trafficking pathway in the risk of PD.

Methods

Linkage disequilibrium score regression was used to estimate PD heritability explained by 252 genes involved in the endocytic membrane-trafficking pathway including genome-wide association studies data from 18,869 cases and 22,452 controls. We used pathway-specific single-nucleotide polymorphisms to construct a polygenic risk score reflecting the cumulative risk of common variants

SUBMITTER: Bandres-Ciga S 

PROVIDER: S-EPMC6467788 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature