The Misclassification of Diffuse Gliomas: Rates and Outcomes.

ABSTRACT:

Purpose

The integrated histopathologic and molecular diagnoses of the 2016 WHO classification of central nervous system tumors have revolutionized patient care by improving diagnostic accuracy and reproducibility; however, the frequency and consequences of misclassification of histologically diagnosed diffuse gliomas are unknown.

Experimental design

Patients with newly diagnosed ICD-O-3 (International Classification of Diseases) histologically encoded diffuse gliomas from 2010-2015 were identified from the National Cancer Database, the misclassification rates and overall survival (OS) of which were assessed by WHO grade and 1p/19q status. In addition, misclassification rates by isocitrate dehydrogenase (IDH), ATRX, and p53 statuses were examined in an analogous multi-institu

SUBMITTER: Iorgulescu JB 

PROVIDER: S-EPMC6467794 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature