The in vitro host cell immune response to bovine-adapted Staphylococcus aureus varies according to bacterial lineage.

ABSTRACT: Mastitis is the most economically important disease affecting dairy cattle worldwide. Staphylococcus aureus is a highly prevalent cause of mastitis, causing infections ranging from sub-clinical to gangrenous. However, the interaction between the genotype of the infecting strain of S. aureus and the host response remains largely uncharacterised. To better understand the variation in presentation and outcomes of S. aureus-mediated bovine mastitis, we studied the interaction of a panel of mastitis isolates from several prominent bovine-associated lineages with bovine mammary epithelial cells (bMEC) and neutrophils. Significant differences in immune gene expression by infected primary or immortalised bMEC, or their elaboration of neutrophil chemoattractants, were observed and were dependent on

SUBMITTER: Murphy MP 

PROVIDER: S-EPMC6467978 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature