Transcriptional activation by MafR, a global regulator of Enterococcus faecalis.

ABSTRACT: Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leading cause of serious infections. Nonetheless, the regulatory pathways involved in its adaptive responses remain poorly understood. We reported previously that the MafR protein of E. faecalis causes genome-wide changes in the transcriptome. Here we demonstrate that MafR functions as a transcription activator. In vivo, MafR increased the activity of the P12294 and P11486 promoters and also the transcription levels of the two genes controlled by those promoters. These genes are pr

SUBMITTER: Ruiz-Cruz S 

PROVIDER: S-EPMC6467988 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature