Radiation Increases Functional KCa3.1 Expression and Invasiveness in Glioblastoma.

ABSTRACT: Glioblastoma (GBM) is a deadly brain tumor, with fast recurrence even after surgical intervention, radio- and chemotherapies. One of the reasons for relapse is the early invasion of surrounding brain parenchyma by GBM, rendering tumor eradication difficult. Recent studies demonstrate that, in addition to eliminate possible residual tumoral cells after surgery, radiation stimulates the infiltrative behavior of GBM cells. The intermediate conductance of Ca²⁺-activated potassium channels (KCa3.1) play an important role in regulating the migration of GBM. Here, we show that high dose radiation of patient-derived GBM cells increases their invasion, and induces the transcription of key genes related to these functions, including the IL-4/IL-4R pair. In addition, we demonstrate

SUBMITTER: D'Alessandro G 

PROVIDER: S-EPMC6468446 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature