Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences.

ABSTRACT: The stability and dynamics of cytoskeleton in brain nerve cells are regulated by microtubule associated proteins (MAPs), tau and MAP2. Both proteins are intrinsically disordered and involved in multiple molecular interactions important for normal physiology and pathology of chronic neurodegenerative diseases. Nuclear magnetic resonance and cryo-electron microscopy recently revealed propensities of MAPs to form transient local structures and long-range contacts in the free state, and conformations adopted in complexes with microtubules and filamentous actin, as well as in pathological aggregates. In this paper, we compare the longest, 441-residue brain isoform of tau (tau40), and a 467-residue isoform of MAP2, known as MAP2c. For both molecules, we present transient structural motifs reveal

SUBMITTER: Melkova K 

PROVIDER: S-EPMC6468450 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature