Ontology highlight
ABSTRACT:
SUBMITTER: Kryczka J
PROVIDER: S-EPMC6468499 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Cells 20190227 3
During tumor development and ongoing metastasis the acquisition of mesenchymal cell traits by epithelial carcinoma cells is achieved through a programmed phenotypic shift called the epithelial-to-mesenchymal transition, EMT. EMT contributes to increased cancer cell motility and invasiveness mainly through invadosomes, the adhesion structures that accompany the mesenchymal migration. The invadosomes and their associated proteases restrict protease activity to areas of the cell in direct contact w ...[more]