Cysteine Cathepsins and their Extracellular Roles: Shaping the Microenvironment.

ABSTRACT: : For a long time, cysteine cathepsins were considered primarily as proteases crucial for nonspecific bulk proteolysis in the endolysosomal system. However, this view has dramatically changed, and cathepsins are now considered key players in many important physiological processes, including in diseases like cancer, rheumatoid arthritis, and various inflammatory diseases. Cathepsins are emerging as important players in the extracellular space, and the paradigm is shifting from the degrading enzymes to the enzymes that can also specifically modify extracellular proteins. In pathological conditions, the activity of cathepsins is often dysregulated, resulting in their overexpression and secretion into the extracellular space. This is typically observed in cancer and inflammation, and cathepsin

SUBMITTER: Vidak E 

PROVIDER: S-EPMC6468544 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature