Pannexin 2 Localizes at ER-Mitochondria Contact Sites.

ABSTRACT: Endomembrane specialization allows functional compartmentalization but imposes physical constraints to information flow within the cell. However, the evolution of an endomembrane system was associated with the emergence of contact sites facilitating communication between membrane-bound organelles. Contact sites between the endoplasmic reticulum (ER) and mitochondria are highly conserved in terms of their morphological features but show surprising molecular diversity within and across eukaryote species. ER-mitochondria contact sites are thought to regulate key processes in oncogenesis but their molecular composition remains poorly characterized in mammalian cells. In this study, we investigate the localization of pannexin 2 (Panx2), a membrane channel protein showing tumor-suppressing prope

SUBMITTER: Le Vasseur M 

PROVIDER: S-EPMC6468579 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature