Untangling Extracellular Proteasome-Osteopontin Circuit Dynamics in Multiple Sclerosis.

ABSTRACT: The function of proteasomes in extracellular space is still largely unknown. The extracellular proteasome-osteopontin circuit has recently been hypothesized to be part of the inflammatory machinery regulating relapse/remission phase alternation in multiple sclerosis. However, it is still unclear what dynamics there are between the different elements of the circuit, what the role of proteasome isoforms is, and whether these inflammatory circuit dynamics are associated with the clinical severity of multiple sclerosis. To shed light on these aspects of this novel inflammatory circuit, we integrated in vitro proteasome isoform data, cell chemotaxis cell culture data, and clinical data of multiple sclerosis cohorts in a coherent computational inference framework. Thereby, we modeled extracellul

SUBMITTER: Dianzani C 

PROVIDER: S-EPMC6468732 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature