Inhibition of NK Reactivity Against Solid Tumors by Platelet-Derived RANKL.

ABSTRACT: NK cells play an important role in tumor immunosurveillance. Their reactivity is governed by various activating and inhibitory surface receptors, which include several members of the TNF/TNF receptor family. For more than 50 years, it has been recognized that tumor immunosurveillance and in particular NK cell antitumor reactivity is largely influenced by platelets, but the underlying mechanisms remain to be fully elucidated. Here we report that upon activation, which reportedly occurs following interaction with cancer cells, platelets upregulate the TNF family member RANKL. Comparative analysis of the expression of RANK among different NK cell subsets and RANKL on platelets in cancer patients and healthy volunteers revealed a distinct malignant phenotype, and platelet-derived RANKL was fou

SUBMITTER: Clar KL 

PROVIDER: S-EPMC6468810 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature