Waveguiding and SERS Simplified Raman Spectroscopy on Biological Samples.

ABSTRACT: Biomarkers detection at an ultra-low concentration in biofluids (blood, serum, saliva, etc.) is a key point for the early diagnosis success and the development of personalized therapies. However, it remains a challenge due to limiting factors like (i) the complexity of analyzed media, and (ii) the aspecificity detection and the poor sensitivity of the conventional methods. In addition, several applications require the integration of the primary sensors with other devices (microfluidic devices, capillaries, flasks, vials, etc.) where transducing the signal might be difficult, reducing performances and applicability. In the present work, we demonstrate a new class of optical biosensor we have developed integrating an optical waveguide (OWG) with specific plasmonic surfaces. Exp

SUBMITTER: Valpapuram I 

PROVIDER: S-EPMC6468818 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature