Physical inactivity, cardiometabolic disease, and risk of dementia: an individual-participant meta-analysis.

ABSTRACT:

Objective

To examine whether physical inactivity is a risk factor for dementia, with attention to the role of cardiometabolic disease in this association and reverse causation bias that arises from changes in physical activity in the preclinical (prodromal) phase of dementia.

Design

Meta-analysis of 19 prospective observational cohort studies.

Data sources

The Individual-Participant-Data Meta-analysis in Working Populations Consortium, the Inter-University Consortium for Political and Social Research, and the UK Data Service, including a total of 19 of a potential 9741 studies.

Review method

The search strategy was designed to retrieve individual-participant data from prospective cohort studies. Exposure was physical inactivity; primary outcomes were incident a

SUBMITTER: Kivimaki M 

PROVIDER: S-EPMC6468884 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature