Reconstitution of the gut microbiota of antibiotic-treated patients by autologous fecal microbiota transplant.

ABSTRACT: Antibiotic treatment can deplete the commensal bacteria of a patient's gut microbiota and, paradoxically, increase their risk of subsequent infections. In allogeneic hematopoietic stem cell transplantation (allo-HSCT), antibiotic administration is essential for optimal clinical outcomes but significantly disrupts intestinal microbiota diversity, leading to loss of many beneficial microbes. Although gut microbiota diversity loss during allo-HSCT is associated with increased mortality, approaches to reestablish depleted commensal bacteria have yet to be developed. We have initiated a randomized, controlled clinical trial of autologous fecal microbiota transplantation (auto-FMT) versus no intervention and have analyzed the intestinal microbiota profiles of 25 allo-HSCT patients (14 who receiv

SUBMITTER: Taur Y 

PROVIDER: S-EPMC6468978 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature