Liquid Biopsies in Lung Cancer: Four Emerging Technologies and Potential Clinical Applications.

ABSTRACT: Background: Liquid biopsies offer a promising alternative to tissue samples, providing non-invasive diagnostic approaches or serial monitoring of disease evolution. However, certain challenges remain, and the full potential of liquid biopsies has yet to be reached. Here we report several methodological approaches to interrogate liquid biopsies using circulating tumour cell (CTC) enumeration and characterisation, transcriptomics, Raman spectroscopy, and copy number instability (CNI) scores using blood samples of lung cancer (LC) patients. Methods: We choose LC; since it still is the most common cause of cancer-related mortality worldwide, and therefore there is a need for development of new non-invasive diagnostic/prognostic technologies. Changes in gene expression were assessed using RNA-s

SUBMITTER: Chudasama D 

PROVIDER: S-EPMC6468998 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature