Effects of high-fat diets on fetal growth in rodents: a systematic review.

ABSTRACT:

Background

Maternal nutrition during pregnancy has life-long consequences for offspring. However, the effects of maternal overnutrition and/ or obesity on fetal growth remain poorly understood, e.g., it is not clear why birthweight is increased in some obese pregnancies but not in others. Maternal obesity is frequently studied using rodents on high-fat diets, but effects on fetal growth are inconsistent. The purpose of this review is to identify factors that contribute to reduced or increased fetal growth in rodent models of maternal overnutrition.

Methods

We searched Web of Science and screened 2173 abstracts and 328 full texts for studies that fed mice or rats diets providing ~ 45% or ~ 60% calories from fat for 3 weeks or more prior to pregnancy. We identified 36 papers m

SUBMITTER: Christians JK 

PROVIDER: S-EPMC6469066 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature