BACE-1 and γ-Secretase as Therapeutic Targets for Alzheimer's Disease.

ABSTRACT: Alzheimer's disease (AD) is a growing global health concern with a massive impact on affected individuals and society. Despite the considerable advances achieved in the understanding of AD pathogenesis, researchers have not been successful in fully identifying the mechanisms involved in disease progression. The amyloid hypothesis, currently the prevalent theory for AD, defends the deposition of β-amyloid protein (Aβ) aggregates as the trigger of a series of events leading to neuronal dysfunction and dementia. Hence, several research and development (R&D) programs have been led by the pharmaceutical industry in an effort to discover effective and safety anti-amyloid agents as disease modifying agents for AD. Among 19 drug candidates identified in the AD pipeline, nine have their mechani

SUBMITTER: Maia MA 

PROVIDER: S-EPMC6469197 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature