Association of the MMP-9 polymorphism and ischemic stroke risk in southern Chinese Han population.

ABSTRACT:

Background

Stroke is a serious cardiovascular disease and is also the leading cause of long-term disability in developing and developed countries. Because matrix metalloproteinase-9 (MMP-9) is associated with the risk of many cardiovascular diseases, we investigated the relationship between single nucleotide polymorphisms (SNPs) in MMP-9 and the risk of Ischemic stroke (IS) in a southern Chinese Han population.

Methods

This study included 250 stroke patients and 250 healthy controls. Genotyping was performed using the Agena MassARRAY system, and chi-squared tests and genetic models were used to evaluate the associations between MMP-9 SNPs and the risk of IS. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression adjusted for a

SUBMITTER: Gao N 

PROVIDER: S-EPMC6469199 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature