Progenitor cell mobilisation and recruitment in pulmonary arteries in chronic obstructive pulmonary disease.

ABSTRACT:

Background

Pulmonary vascular abnormalities are a characteristic feature of chronic obstructive pulmonary disease (COPD). Cigarette smoking is the most important risk factor for COPD. It is believed that its constant exposure triggers endothelial cell damage and vascular remodelling. Under pathological conditions, progenitor cells (PCs) are mobilized from the bone marrow and recruited to sites of vascular injury. The aim of the study was to investigate whether in COPD the number of circulating PCs is related to the presence of bone marrow-derived cells in pulmonary arteries and the association of these phenomena to both systemic and pulmonary endothelial dysfunction.

Methods

Thirty-nine subjects, 25 with COPD, undergoing pulmonary resection because of a localized carcinoma,

SUBMITTER: Tura-Ceide O 

PROVIDER: S-EPMC6469212 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature