Dietary intake of nutrients involved in folate-mediated one-carbon metabolism and risk for endometrial cancer.

ABSTRACT:

Background

Studies disagree as to whether intakes of folate-mediated one-carbon metabolism nutrients are associated with endometrial cancer.

Methods

Using data from the large, prospective NIH-AARP Diet and Health Study, we used Cox proportional hazards models to evaluate endometrial cancer risk associated with calorie-adjusted dietary intake of several B vitamins and methionine. All models accounted for age, race, body mass index (BMI), smoking, oral-contraceptive use, menopausal hormone therapy use and caloric intake. We estimated associations by time from baseline (≤3 or >3 years) and stratified models by BMI (<25 or ≥25 kg/m2). During 16 years of follow-up, we identified 2329 endometrial cancer cases among 114 414 participants.

Results

After adjustment for confound

SUBMITTER: Lu J 

PROVIDER: S-EPMC6469295 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature