Biological Variability of Estimated GFR and Albuminuria in CKD.

ABSTRACT:

Rationale & objective

Determining whether a change in estimated glomerular filtration rate (eGFR) or albuminuria is clinically significant requires knowledge of short-term within-person variability of the measurements, which few studies have addressed in the setting of chronic kidney disease.

Study design

Cross-sectional study with multiple collections over less than 4 weeks.

Setting & participants

Clinically stable outpatients with chronic kidney disease (N=50; mean age, 56.8 years; median eGFR, 40mL/min/1.73m²; median urinary albumin-creatinine ratio (UACR), 173mg/g).

Exposure

Repeat measurements from serially collected samples across 3 study visits.

Outcomes

Measurements of urine albumin concentration (UAC), UACR, and plasma creatinine, cys

SUBMITTER: Waikar SS 

PROVIDER: S-EPMC6469385 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature